Cissus Quadrangularis. Max Bioavailability. Ultra Micronized. Healthy Joints and Cartilage. Support Optimal Health Joint. Improve Joint Comfort & Recovery. Cissus Quadranularis is a natural extract. Cissus Quadrangularis is a type of vine in the grape family. Extracts from this plant have been used in classical medicine for centuries. This succulent vine, which grows naturally in Africa and Asia, is still well regarded today for its unique healing and health benefits. Antioxidant Joint Support. Cissus Quadrangularis contains several unique saponins and anti-oxidants. It has been clinically studied for its support in joint, ligament, and tendon health. Studies suggest that Cissus Quadrangularis may provide a range of benefits for soft tissue health, while also contributing to a healthy anti-inflammatory response. Inflammation Support. Controlling inflammation is extremely important to overall health and wellness, especially for those who lead an active lifestyle.